PARADIGM SHIFTS IN GYNECOLOGIC ONCOLOGY
Learning with friends
GUARDA IL VIDEO
CONFERENCE SUMMARY
Over the last years, some scientific publications dramatically impacted the management of gynecological cancers. In this context, we organized an event to share the results of the most significant studies, which somehow represented a paradigm shift in uterine, cervical, and ovarian cancers.
A two-days conference will give the chance to the attendances to understand the meaning of working in teams, learning from mentors and friends. High-level national and international speakers will share their expertise and will deliver inspiring talks with unique insights. The proposed topics will be presented with reference to evidence-based medicine and in accordance with the most recent national and international guidelines.
Mixed in-person and virtual interactive sessions will give the opportunity to question leading experts and be inspired by best practices from different countries.
The meeting is intended for gynecologic oncologists, medical oncologists, radiation oncologists, pathologists, general gynecologists, nurses, residents and physician other clinicians involved in the care of patients with gynecologic malignancies.
PROGRAM
Two days together to examine in depth all the aspects of gynecologic oncology in a climate of friendship and thirst for knowledge
Thursday, July 01
15.00 – Registration
15.30 – Opening session – J. Casarin
15.45 – Gynecologic Oncology at “Del Ponte Hospital” of Varese: past present and future perspectives – F. Ghezzi
Session 1. OVARIAN CANCER
Chair: : P. Beretta / A. Ditto / G. Scambia
16:15 – Early detection in ovarian cancer – A. Ahmed
16:45 – Improving the outcome of early ovarian cancer treatment – S. Uccella
17:05 – Radical surgery in ovarian cancer: morbidity and oncological outcomes – G. Aletti
17:25 – Neoadjuvant chemotherapy for advanced stage ovarian cancer: how to select the patients? – L. Tortorella
17:45 – Adjuvant treatment following cytoreductive surgery for advanced stage ovarian cancer: updates and latest evidence – N. Colombo
18:05 – Role of surgery in recurrent ovarian cancer – A. Du Bois
18:25 – Discussion /Q&A/ OVARIAN CANCER – A. Ahmed – G. Aletti – N. Colombo – A. du Bois – L. Tortorella – S. Uccella
18:45 – Daily final remarks
Friday, July 02
08.30 – Registration
Session 2. IMPROVEMENT IN GYNECOLOGIC CANCER CARE
Chair: A. Buda / V. Di Donato / F. Odicino
09:00 – Clinical application of molecular biology and cancer genetics in ovarian cancers – T.Grassi
09:25 – Advanced ultrasound evaluation for gynecologic malignancies: the actual impact on the preoperative work-up – D. Sturla
09:50 – Enhanced Recovery After Surgery (ERAS): a multidisciplinary, multi-modal approach to perioperative care in gynecologic oncology – G. Salvo
10:15 – Challenges and barriers to implementation of the ERAS pathway in Italy – F. Ferrari
10:45 – Discussion / Q&A / IMPROVEMENT IN GYNECOLOGIC CANCER CARE – F. Ferrari – T. Grassi – G. Salvo – D. Sturla
11.00 – Coffee break
Session 3. CERVICAL CANCER
Chair: M. Franchi / F. Raspagliesi
11.30 – The Role of Human Papillomavirus Vaccines in Cervical Cancer: Prevention and Treatment – G. Bogani
12.00 – Surgical treatment for apparent early stage cervical cancer: back to the “open” forever? – P. Ramirez
12.20 – Sentinel lymph node for cervical cancer staging – A.Buda
12:40 – Contraindication to NACT and surgery in locally advanced cervical cancer – F. Landoni
13:00 – Discussion /Q&A/ CERVICAL CANCER – G. Bogani – A. Buda – F. Landoni – P. Ramirez
13.30 – Box Lunch
14.30 – Friendship in science and medicine – N. Abu-Rustum – A. Mariani – P. Ramirez
Session 4. ENDOMETRIAL CANCER
Chair: F. Ghezzi / S. Greggi / V. Zanagnolo
15:10 – Minimally invasive surgery in endometrial cancer: the long and winding road to reduce morbidity – S. Cappuccio
15:30 – Lymphadenectomy vs. sentinel lymph node biopsy: surgical and oncological outcomes – A. Papadia
15:50 – The “5Ws”of adjuvant treatment in endometrial cancer: What – When – Where – to Whom and Why? – A. Mariani
16:10 – New perspectives on the management of endometrial cancer – the role of molecular classification – F. Multinu
16:30 – Discussion /Q&A/ ENDOMETRIAL CANCER – S. Cappuccio – A. Mariani – F. Multinu – A. Papadia
17:30 – Final Tests
FABIO GHEZZI
President
JVAN CASARIN
Scientific Chair
SERENA CAPPUCCIO
Scientific Committee
FRANCESCO MULTINU
Scientific Committee
FACULTY
NADEEM R. ABU-RUSTUM NEW YORK, NY USA
AHMED A. AHMED OXFORD, UK
GIOVANNI ALETTI MILAN, ITALY
PAOLO BERETTA COMO, ITALY
GIORGIO BOGANI MILAN, ITALY
ALESSANDRO BUDA MONZA, ITALY
SERENA CAPPUCCIO ROME, ITALY
JVAN CASARIN VARESE, ITALY
NICOLETTA COLOMBO MILAN, ITALY
VIOLANTE DI DONATO ROME, ITALY
ANTONINO DITTO MILAN, ITALY
ANDREAS DU BOIS ESSEN, GERMANY
FEDERICO FERRARI BRESCIA, ITALY
MASSIMO FRANCHI VERONA, ITALY
FABIO GHEZZI VARESE, ITALY
TOMMASO GRASSI MONZA, ITALY
STEFANO GREGGI NAPLES, ITALY
FABIO LANDONI MONZA, ITALY
ANDREA MARIANI ROCHESTER, MN, USA
FRANCESCO MULTINU MILAN, ITALY
FRANCO ODICINO BRESCIA, ITALY
ANDREA PAPADIA LUGANO, SWITZERLAND
PEDRO RAMIREZ HOUSTON, TX, USA
FRANCESCO RASPAGLIESI MILAN, ITALY
GLORIA SALVO HOUSTON, TX, USA
GIOVANNI SCAMBIA ROME, ITALY
DAVIDE STURLA VARESE, ITALY
LUCIA TORTORELLA ROME, ITALY
STEFANO UCCELLA VERONA, ITALY
VANNA ZANAGNOLO MILAN, ITALY
JVAN CASARIN
Date of birth: September 29, 1985
Nationality: Italian
Current Position:
September 2018 – Present: Research Associate, University of Insubria Varese (Italy).
Septeber 2018 – Present: Consultant of Obstetrics and Gynecology, Women’s and Children Hospital, Varese (Italy).
February 2018 – Present: Research Collaborator, Division of Gynecology Surgery, Department of Obstetrics and Gynecologic, Mayo Clinic, Rochester, Minnesota (USA)
Education and Training:
CLINICAL Fellowship: Gynecologic oncology_2017-2018
Oxford University Hospital, Gynaecologic Oncology (Churchill NHS-Hospital), Oxford, UK.
Research Fellowship: Gynecologic oncology_2016-2017
Mayo Clinic Rochester, MN, USA -Mentorship: Prof. Dr. Andrea Mariani residency program – obstetrics and gynecology_2012-2017
University of Insubria Varese (Italy)
Scientific contributions:
Author of more than 120 peer reviewed articles and 5 book chapters, primarily focused on gynecologic cancers and minimally invasive surgery
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Education and training |
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July 2012 |
Degree in Medicine and Surgery at the Catholic University of the Sacred Heart of Rome with full honors |
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2013-2014 October 2018-February 2019
December 2014- December 2019 |
Residency in Medical Oncology Visiting Research Fellowship in Gynaecologic Oncology at Mayo Clinic Rocheste Residency in Obstetrics and Gynecology (5-year program) Vote 50 / 50 (GPA 4.0), cum laude |
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Personal skills and competences |
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Mother tongue |
Italian |
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Other languages |
English |
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Scientific activity |
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Participation in clinical trials |
Participation as Sub-Investigator in multicenter, international clinical Phase II-III trials conducted in Good Clinical Practice
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Scientific production
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– Sentinel lymph node biopsy for robotic-assisted endometrial cancer staging: further improvement of perioperative outcomes. Casarin J, Multinu F, Tortorella L, Cappuccio S, Weaver AL, Ghezzi F, Cilby W, Kumar A, Langstraat C, Glaser G, Mariani A. Int J Gynecol Cancer. 2019 Nov 27. pii: ijgc-2019-000672. doi: 10.1136/ijgc-2019-000672. PMID: 31780567 -Implementing robotic surgery for uterine cancer in the United States: Better outcomes without increased costs. Casarin J, Song C, Multinu F, Cappuccio S, Liu E, Butler KA, Glaser GE, Cliby WA, Langstraat CL, Ghezzi F, Fu AZ, Mariani A. Gynecol Oncol. 2019 Nov 25. pii: S0090-8258(19)31667-1. doi: 10.1016/j.ygyno.2019.11.016. PMID: 31780236 -Sentinel lymph node biopsy with cervical injection of indocyanine green in apparent early-stage endometrial cancer: predictors of unsuccessful mapping. Tortorella L, Casarin J, Multinu F, Cappuccio S, McGree ME, Weaver AL, Langstraat CL, Keeney GL, Kumar A, Melis GB, Angioni S, Scambia G, Mariani A, Glaser GE.Gynecol Oncol. 2019 Oct;155(1):34-38. doi: 10.1016/j.ygyno.2019.08.008. Epub 2019 Aug 8. PMID: 31402166 -Predictors of extensive lymphatic dissemination and recurrences in node-positive endometrial cancer. Zanfagnin V, Huang Y, Mc Gree ME, Weaver AL, Casarin J, Multinu F, Cappuccio S, Ferrero A, Mariani A, Glaser GE. Gynecol Oncol. 2019 Sep;154(3):480-486. doi: 10.1016/j.ygyno.2019.07.006. Epub 2019 Jul 16.PMID: 31324453 – Ultrastaging of negative pelvic lymph nodes to decrease the true prevalence of isolated paraaortic dissemination in endometrial cancer. Multinu F, Casarin J, Cappuccio S, Keeney GL, Glaser GE, Cliby WA, Weaver AL, McGree ME, Angioni S, Faa G, Leitao MM Jr, Abu-Rustum NR, Mariani A. Gynecol Oncol. 2019 Jul;154(1):60-64. doi: 10.1016/j.ygyno.2019.05.008. Epub 2019 May 22. PMID: 31126637 -Minimally Invasive Pelvic Exenteration for Gynecologic Malignancies: AMulti-Institutional Case Series and Review of the Literature Nicolo Bizzarri, Vito Chiantera, Alfredo Ercoli, Anna Fagotti, Lucia Tortorella, Carmine Conte, Serena Cappuccio, Mariano Catello Di Donna, Valerio Gallotta, Giovanni Scambia, and Giuseppe Vizzielli https://doi.org/10.1016/j.jmig.2018.12.019 -Assessment of preoperative nutritional status using BIA-derived phase angle (PhA) in patients with advanced ovarian cancer: Correlation with the extent of cytoreduction and complications Stefano Uccella a,⁎, Maria Cristina Mele b, Lorena Quagliozzi a, Emanuele Rinninella b,c, Camilla Nero d, Serena Cappuccio d, Marco Cintoni b, Antonio Gasbarrini c, Giovanni Scambia a,d, Anna Fagotti a,d Gynecologic Oncology 149 (2018) 263–269 -Resectability and Vascular Management of Retroperitoneal Gynecological Malignancies: A Large Single-Institution Case-Series Giovanni Tinelli1, Serena Cappuccio2, Ezio Parente1, Anna Fagotti2, Valerio Gallotta2, Carmine Conte2, Barbara Costantini2, Salvatore Gueli Alletti2, Giovanni Scambia2 And Giuseppe Vizzielli2 Anticancer Research 37 -Secondary cytoreduction in ovarian cancer: who really benefits? Maria Teresa Giudice1 · Marco D’Indinosante1 · Serena Cappuccio1 · Valerio Gallotta1 · Anna Fagotti1 ·Giovanni Scambia1 · Marco Petrillo2,3 Archives of Gynecology and Obstetrics https://doi.org/10.1007/s00404-018-4915-1 – Total Laparoscopic (S-LPS) versus TELELAP ALF-X Robotic-Assisted Hysterectomy: A Case-Control Study. Fanfani F, Restaino S, Rossitto C, Gueli Alletti S, Costantini B, Monterossi G, Cappuccio S, Perrone E, Scambia G. J Minim Invasive Gynecol. 2016 Sep-Oct;23(6):933-8. doi: 10.1016/j.jmig.2016.05.008. Epub 2016 May 28. PMID: 27247263 – Robotic versus laparoscopic surgery in gynecology: which should we use? Fanfani F, Restaino S, Ercoli A, Chiantera V, Fagotti A, Gallotta V, Monterossi G, Cappuccio S, Scambia G. Minerva Ginecol. 2016 Aug;68(4):423-30. Epub 2015 Dec 3. Review. PMID: 26633042 – [The ISP (Safe Insertion of PICCs) protocol: a bundle of 8 recommendations to minimize the complications related to the peripherally inserted central venous catheters (PICC)]. Emoli A, Cappuccio S, Marche B, Musarò A, Scoppettuolo G, Pittiruti M; Gruppo Aperto di Studio sugli Accessi Venosi Centrali a Lungo Termine. Assist Inferm Ric. 2014 Apr-Jun;33(2):82-9. doi: 10.1702/1539.16813. Italian. PMID: 25002059 – Association of IL-8 and eNOS polymorphisms with clinical outcomes in bevacizumab-treated breast cancer patients: an exploratory analysis. Di Salvatore M1, Lo Giudice L2, Rossi E2, Santonocito C3, Nazzicone G2, Rodriquenz MG2, Cappuccio S2, Inno A2,4, Fuso P2, Orlandi A2, Strippoli A2, Capoluongo E3, Astone A2, Cassano A2, Barone C2. Clin Transl Oncol. 2016 Jan;18(1):40-6. doi: 10.1007/s12094-015-1334-7. Epub 2015 Jul 4. |
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Abstract and poster presentation at scientific meetings/conferences |
– TEMPORAL TRENDS, ENABLING FACTORS, COST AND SAFETY IMPLICATIONS OF SHIFTING HYSTERECTOMY FOR ENDOMETRIAL CANCER FROM INPATIENT TO OUTPATIENT SETTING IN THE US S. Cappuccio1,L. Yanli2, L. Emeline2, S. Chao2, G. Glaser1, J. Casarin1, T. Grassi1, K. Butler3, P. Magtibay3, J. Magrina3, A. Mariani1, C. Langstraat1. Abstract_ IGCS Kyoto 2019 – MACHINE LEARNING ALGORITHM ACCURACY IN PREDICTING LYMPH NODE INVOLVEMENT IN ENDOMETRIAL CANCER Cappuccio S., Zanfagnin V., Glaser G.E., Grassi T., Scambia G., Hart, S.N., Mariani A. Abstract_ IGCS Kyoto 2018 – Exploratory analysis of Circultaing Tumor DNA as biomarker of disease spread in Endometrial cancer Tommaso Grassi 1,2,*, Faye R. Harris 3,*, James Smadbeck 3, Stephen J. Murphy 3, Matthew Block 4, Francesco Multinu 1, Janet L. Schaefer Klein 3, Piyan Zhang 3, Giannoula Karagouga 3, Maureen A. Lemens 1, Marla Kay S. Sommerfield 1, Serena Cappuccio 1,5, George Vasmatzis 3,** and Andrea Mariani 1,** Abstract_ IGCS Kyoto 2018 -Circulating Tumor DNA in Endometrial Cancer: Creating Individualized Tumor Panels Faye R. Harris[1]*, Tommaso Grassi[2,3]*, James Smadbeck[1], Stephen J. Murphy[1], Matthew Block[4], Francesco Multinu[2], Janet L. Schaefer Klein[1], Piyan Zhang[1], Giannoula Karagouga[1], Serena Cappuccio[3], George Vasmatzis[1]** and Andrea Mariani[2]**. – Individualizing Medicine conference, Rochester 2018Targeting p53 as a promising novel strategy for the treatment of high-grade endometrial cancer (HGEC): preliminary data on patient-derived three-dimensional (PD3D) cellular models S. Cappuccio1, R. Feathers2, S. J. Weroha3, Vasmatzis 4, M. De Andrade5, E. Polley5 , G. Keeney6, P. Z. Anastasiadis2,*, A. Mariani1,*Abstract_ Mayo Clinic-Karolinska Institutet conference, Rochester 2018 – A NEW WIRELESS ULTRASOUND PROBE FOR ULTRASOUND GUIDED CENTRAL VENOUS ACCESS M. Pittiruti 1, A Emoli2, S. Cappuccio2, A. La Greca1
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FRANCESCO MULTINU
Gynecologic Oncology Fellow presso IEO Istituto Europeo di Oncologia
Milan Area, Italy
Experiences:
IEO Istituto Europeo di Oncologia
Gynecologic Oncology Fellow – gennaio 2018 – Present (2 anni 2 mesi)
Milano, Italia
Division of Gynecologic Cancer Surgery
Mayo Clinic – 5 anni 6 mesi
Research Collaborator
febbraio 2018 – Present (2 anni 1 mese) – Rochester, Minnesota, Stati Uniti
Division of Gynecologic Surgery
Research Fellow
settembre 2014 – gennaio 2018 (3 anni 5 mesi)
Rochester, Minnesota, Stati Uniti
Division of Gynecologic Surgery
Education:
Mayo Clinic Graduate School of Biomedical Sciences
Master in Clinical and Translational Research · (2015 – 2017)
Università degli Studi di Cagliari
Residency, Obstetrics and Gynecology · (2012 – 2017)
Università degli Studi di Sassari
Doctor of Medicine (M.D.), Medicina · (2004 – 2011)
Primary skills:
Gynecology
Gynecologic Oncology
Clinical Research
Languages:
Italiano (Native or Bilingual)
Inglese (Professional Working)
FABIO GHEZZI
DATE AND PLACE OF BIRTH:
May 31, 1966, Pavia, Italy
CURRENT POSITION:
Full Professor of Obstetrics and Gynecology
Director Ob/Gyn ResidencyProgram
University of Insubria Varese, Italy
Adjunct Professor University of Wien
Honorary Member British Society of Gynecological Endoscopy
EDUCATION:
1995 Board Eligible in Obstetric and Gynecology
“University of Insubria, Varese, Italy”
1991 M.D. Degree
“Universita’ degli studi di Pavia”
1985 Diploma. Major: Scientific Studies.
T. Taramelli Liceo, Pavia, Italy
TRAINING:
08/01/2013 – Present Head Obstetrics and Gynecology Dept Director Ob/Gyn Residency Program – University of Insubria, Varese, Italy
07/01/2010 – Present Head Gynecologic Oncologic Unit – University of Insubria, Varese, Italy
01/09/2002 – 06/30/2010 Associate Professor of Ob/Gyn – University of Insubria, Varese, Italy
01/11/1997 – 31/08/2002 Assistant Professor of Ob/Gyn – University of Insubria, Varese, Italy
01/10/1997 – 31/10/1999 Attending Physician Dept Ob/Gyn – Regional Hospital – Lugano, Switzerland
01/10/1996 – 30/09/1997 Research assistant Dept. Obstetrics and Gynecology – Universitas Frauenklinik, Basel, Switzerland
01/08/1996 – 31/08/1996 Visiting Fellow Maternal – Fetal Medicine – Wayne State University/Hutzel Hospital – Perinatology Research Branch – National Institute of Child Health and Human Development – Detroit, Michigan, USA
01/3/1996 – 31/07/1996 Research assistant Dept. Obstetrics and Gynecology “University of Pavia” II Faculty, Varese, Italy
01/01/1996 – 29/02/1996 Post-Doctoral research fellowship “Prematur labor and prenatal diagnosis of congenital anomalies” Wayne State University/Hutzel Hospital, Department of Obstetrics and Gynecology, Detroit, Michigan, U.S.A.
01/10/1995 – 31/12/1995 Clinical Fellowship Maternal – Fetal Medicine Ben Gurion University of the Nagev – Dipartimento di Ostetricia e Ginecologia – High-Risk Pregnacy Unit Beer-Sheva, Israel
01/07/1994 – 30/09/1995 Post-Doctoral research fellowship “Premature labor and prenatal diagnosis of congenital anomalies” Georgetown University/ Perinatology Research Branch/National Institute of Child Health and Human Development, Washington DC, U.S.A.
01/04/1994 – 30/06/1994 Post-Doctoral research fellowship “Premature labor and prenatal diagnosis of congenital anomalies” Wayne State University/Hutzel Hospital, Department of Obstetrics and Gynecology, Detroit, Michigan, U.S.A.
01/01/1994 – 30/03/1994 Training period in prenatal diagnosis of congenital anomalies University of Bologna, Italy, Department of Obstetrics and Gynecology, Section of Fisiopathology of Reproduction.
1991-1994 Post graduate training in Obstetrics and Gynecology “University’ of Pavia”, Italy
1985-1991 School of Medicine, “University of Pavia”, Italy
PROFESSIONAL SOCIETIES:
Past President of the Italian Society of Gynecological Surgery
Member of the Board of the Italian Society of Gynecological Oncology
Member of the Board of the Lumbard Socierty of Obstetrics and Gynecology
Member of the Special Interest Group Oncology of the ESGE
ETHICAL COMMITTEE:
08/01/2014 – 31/12/2017 Member of the Regional Ethical Committee
GRANT SUPPORT:
1991-1995 “University of Pavia”: Post-graduate training in Ob/Gyn
1994-1996 Scholarship award from the Fogarty Foundation National Institute of Health, U.S.A.
1996 Scholarship award from University of Pavia, II Faculty in Varese
1996 Scholarship award from Hospital “Di Circolo”, Varese, Italy to conduct research in the field of prenatal diagnosis
1997 Scholarship award “Claudio Miglierina” from the Italian Government to conduct research on “Fetal cells isolation in maternal blood” at University of Basel, Basel, Switzerland